N-Substituted arylsulfonamide building blocks as alternative submonomers for peptoid synthesis

DC FieldValueLanguage
dc.contributor.authorVézina-Dawod, Simon-
dc.contributor.authorDerson, Antoine-
dc.contributor.authorBiron, Éric-
dc.date.accessioned2016-04-27T17:41:25Z-
dc.date.available2017-01-08T05:00:00Z-
dc.date.issued2015-01-08-
dc.identifier.issn0040-4039fr_CA
dc.identifier.urihttp://hdl.handle.net/20.500.11794/880-
dc.description.abstractPeptoids (oligo N-substituted glycines) are peptidomimetic oligomers showing attractive structural and pharmacological properties. The efficiency of their synthesis has prompted the use of peptoids in combinatorial libraries. To increase the chemical diversity accessible in peptoid design and libraries, we demonstrate here that N-substituted o-nitrobenzenesulfonamide derivatives can be used as alternative building blocks in the synthesis of peptoids by the submonomer approach. The preparation of N,O-protected amino alcohol submonomers and the conditions for their incorporation into peptoid oligomers are reported. The described method is compatible with the submonomer approach and was applied to prepare peptoid oligomers bearing different hydroxylated side chains.fr_CA
dc.description.abstractKeywords : Peptoids; Peptidomimetics; Solid-phase synthesis; Nitrobenzenesulfonamidesfr_CA
dc.languageengfr_CA
dc.publisherElsevierfr_CA
dc.subjectPeptoidsfr_CA
dc.subjectPeptidomimeticsfr_CA
dc.subjectSolid-phase synthesisfr_CA
dc.subjectNitrobenzenesulfonamidesfr_CA
dc.titleN-Substituted arylsulfonamide building blocks as alternative submonomers for peptoid synthesisfr_CA
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherche-
dcterms.bibliographicCitationTetrahedron letters, Vol. 56 (2), 382–385 (2015)fr_CA
dc.audienceProfesseurs (Enseignement supérieur)fr_CA
dc.audienceÉtudiantsfr_CA
dc.audienceDoctorantsfr_CA
dc.audienceBiochimistesfr_CA
dc.identifier.doi10.1016/j.tetlet.2014.11.104fr_CA
dc.subject.rvmComposés organiques -- Synthèsefr_CA
dc.subject.rvmOligomèresfr_CA
dc.subject.rvmMonomèresfr_CA
dc.subject.rvmPeptoïdesfr_CA
rioxxterms.versionAccepted Manuscriptfr_CA
rioxxterms.version_of_recordhttps://doi.org/10.1016/j.tetlet.2014.11.104fr_CA
rioxxterms.project371503-2010fr_CA
rioxxterms.project.funder_nameNatural Sciences and Engineering Research Council of Canadafr_CA
bul.rights.periodeEmbargo24 moisfr_CA
Collection:Articles publiés dans des revues avec comité de lecture

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