Preparation of N-substituted N-arylsulfonylglycines and their use in peptoid synthesis

Authors: Jobin, SteveVézina-Dawod, Simon; Herby, Claire; Derson, Antoine; Biron, Éric
Abstract: To increase the chemical diversity accessible with peptoids and peptide-peptoid hybrids, N-alkylated arylsulfonamides were used to prepare side chain protected N-substituted glycines compatible with solid-phase synthesis. The described procedures give access to peptoid monomers bearing a wide variety of functional groups from commercially available amines in four straightforward steps. The prepared N-substituted N-arylsulfonylglycines were used as monomers in solid-phase synthesis to introduce relevant functionalized side chains into peptoid oligomers and peptide-peptoid hybrids.
Document Type: Article de recherche
Issue Date: 9 November 2015
Open Access Date: 9 November 2016
Document version: AM
This document was published in: Organic letters, Vol. 17 (22), 5626-5629 (2015)
American Chemical Society
Alternative version: 10.1021/acs.orglett.5b02862
Collection:Articles publiés dans des revues avec comité de lecture

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