Preparation of N-substituted N-arylsulfonylglycines and their use in peptoid synthesis
Authors: | Jobin, Steve; Vézina-Dawod, Simon; Herby, Claire; Derson, Antoine; Biron, Éric |
Abstract: | To increase the chemical diversity accessible with peptoids and peptide-peptoid hybrids, N-alkylated arylsulfonamides were used to prepare side chain protected N-substituted glycines compatible with solid-phase synthesis. The described procedures give access to peptoid monomers bearing a wide variety of functional groups from commercially available amines in four straightforward steps. The prepared N-substituted N-arylsulfonylglycines were used as monomers in solid-phase synthesis to introduce relevant functionalized side chains into peptoid oligomers and peptide-peptoid hybrids. |
Document Type: | Article de recherche |
Issue Date: | 9 November 2015 |
Open Access Date: | 9 November 2016 |
Document version: | AM |
Permalink: | http://hdl.handle.net/20.500.11794/879 |
This document was published in: | Organic letters, Vol. 17 (22), 5626-5629 (2015) https://doi.org/10.1021/acs.orglett.5b02862 American Chemical Society |
Alternative version: | 10.1021/acs.orglett.5b02862 26550851 |
Collection: | Articles publiés dans des revues avec comité de lecture |
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