Metabolic syndrome: the danger signal in atherosclerosis

Authors: Mathieu, PatrickPibarot, PhilippeDesprés, Jean-Pierre
Abstract: Atherosclerosis is a chronic inflammatory disease characterized by infiltration of blood vessels by lipids and leukocytes. There is a growing body of evidence that among risk factors that promote atherosclerosis, the metabolic syndrome is a powerful and prevalent predictor of cardiovascular events. The systemic inflammatory process associated with the metabolic syndrome has numerous deleterious effects that promote plaque activation, which is responsible for clinical events. Interactions between the innate immune system with lipidderived products seem to play a major role in the pathophysiology of atherosclerosis in relation with the metabolic syndrome. The multiple links among adipose tissue, the vascular wall, and the immune system are the topics of this review, which examines the roles of oxidized lowdensity lipoprotein, inflammatory cytokines, and adipokines in triggering and perpetuating a danger signal response that promotes the development of atherosclerosis. Furthermore, therapeutic options that specifically target the metabolic syndrome components are reviewed in light of recent developments.
Document Type: Article de recherche
Issue Date: 1 September 2006
Open Access Date: 7 July 2016
Document version: VoR
This document was published in: Vascular Health and Risk Management, Vol. 2 (3), 285–302 (2006)
Dove Medical Press
Alternative version: 17326334
Collection:Articles publiés dans des revues avec comité de lecture

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