Age-related differences in the pathogenesis of calcific aortic stenosis : the potential role of resistin

Auteur(s): Mohty, Dania; Pibarot, PhilippeDesprés, Jean-PierreCartier, AmélieArsenault, BenoitPicard, FrédéricMathieu, Patrick
Résumé: Background: Aortic stenosis (AS) is considered as an atherosclerotic related process. However, there are uncertainties whether AS in the elderly is associated with the same pathophysiological processes as in younger patients. We hypothesized that the metabolic determinants of the valvular inflammatory and calcifying processes occurring in elderly patients are different from those observed earlier in life. Methods: Among 114 patients operated for a severe AS, a complete plasma lipid blood profile and plasma levels of adipokines (resistin, leptin) were determined. The calcium content of the aortic valve was measured and valvular inflammation was quantified. Results Elderly patients (= 70 years) had significantly lower LDL-C ( p = 0.02), lower LDL-C associated with small size particles (LDL-C < 255 Å) ( p = 0.003), and higher HDL peak particle size than younger patients ( p = 0.03). In addition, elderly patients had increased plasma leptin ( p = 0.04) and resistin ( p = 0.0004) levels compared to the middle-aged group (< 70 years). In the elderly patients, higher plasma resistin blood levels were associated with increased valve calcium content and inflammation. Conclusion: The lipid profile of elderly patients was found less atherogenic than that of middle-aged patients. On the other hand, older patients with AS had higher plasma level of resistin which was associated with the degree of valvular calcification and inflammation. These results suggest that, beyond lipid model of atherosclerosis, age-related processes affecting resistin blood levels may also be involved in the late development of AS.
Type de document: Article de recherche
Date de publication: 21 janvier 2009
Date de la mise en libre accès: Accès restreint
Version du document: VoR
Lien permanent: http://hdl.handle.net/20.500.11794/7952
Ce document a été publié dans: International Journal of Cardiology, Vol. 142 (2), 126–132 (2010)
https://doi.org/10.1016/j.ijcard.2008.12.068
Elsevier
Autre version disponible: 10.1016/j.ijcard.2008.12.068
19162347
Collection :Articles publiés dans des revues avec comité de lecture

Fichier(s) :
Description TailleFormat 
Mohty2010-11389.pdf
149.34 kBAdobe PDF    Demander une copie
Tous les documents dans CorpusUL sont protégés par la Loi sur le droit d'auteur du Canada.