Pim-1 : a new biomarker in pulmonary arterial hypertension

DC FieldValueLanguage
dc.contributor.authorRenard, Sébastien-
dc.contributor.authorPaulin, Roxane-
dc.contributor.authorBreuils-Bonnet, Sandra-
dc.contributor.authorSimard, Serge-
dc.contributor.authorPibarot, Philippe-
dc.contributor.authorBonnet, Sébastien-
dc.contributor.authorProvencher, Steeve-
dc.date.accessioned2016-06-28T13:04:05Z-
dc.date.available2016-06-28T13:04:05Z-
dc.date.issued2013-01-01-
dc.identifier.issn2045-8932fr_CA
dc.identifier.urihttp://hdl.handle.net/20.500.11794/7552-
dc.description.abstractProvirus integration site for Moloney murine leukemia virus (Pim-1) is an oncoprotein overexpressed in lungs from pulmonary arterial hypertension (PAH) patients and involved in cell proliferation via the activation of the NFAT/STAT3 signaling pathway. We hypothesized that Pim-1 plasma levels would predict the presence of PAH and correlate with disease severity. Pim-1 plasma levels were measured at the time of catheterization in 49 PAH patients, including nonvasoreactive (n = 19) and vasoreactive idiopathic PAH (n = 5), and PAH related to connective tissue disease (n = 16) and congenital heart disease (n = 9). Fifty controls were also recruited. The capacity of Pim-1 to discriminate PAH from controls and its association with disease severity were assessed. Pim-1 plasma levels were higher in PAH than in controls (9.6 ± 4.0 vs. 7.2 ± 2.4 ng/mL, P < 0.01). Pim-1 appropriately discriminated proliferative PAH from controls (AUC = 0.78 to 0.94 using ROC curves). Among PAH patients, Pim-1 correlated with traditional markers of PAH severity. The 1-year survival was 97% and 47% for PAH patients with baseline Pim-1 levels lower and higher than 11.1 ng/mL, respectively (HR 11.4 (3.3–39.7); P <0.01). After adjustment for hemodynamic and biochemical variables, Pim-1 levels remained an independent predictor of mortality (P < 0.01). Pim-1 is a promising new biomarker in PAH.fr_CA
dc.languageengfr_CA
dc.publisherUniversity of Chicago Pressfr_CA
dc.subjectBiomarkerfr_CA
dc.subjectOncoproteinfr_CA
dc.subjectPim-1fr_CA
dc.subjectPrognosisfr_CA
dc.subjectPulmonary arterial hypertensionfr_CA
dc.subjectPulmonary vascular remodelingfr_CA
dc.titlePim-1 : a new biomarker in pulmonary arterial hypertensionfr_CA
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherche-
dcterms.bibliographicCitationPulmonary circulation, Vol. 3 (1), 74-84 (2013)fr_CA
dc.audienceCardiologuesfr_CA
dc.audienceMédecinsfr_CA
dc.audienceProfesseurs (Enseignement supérieur)fr_CA
dc.audienceDoctorantsfr_CA
dc.audienceÉtudiantsfr_CA
dc.identifier.doi10.4103/2045-8932.109917fr_CA
dc.identifier.pubmedhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641743/fr_CA
dc.subject.rvmHypertension pulmonairefr_CA
dc.subject.rvmMarqueurs biologiquesfr_CA
rioxxterms.versionVersion of Recordfr_CA
rioxxterms.version_of_recordhttps://doi.org/10.4103/2045-8932.109917fr_CA
rioxxterms.project.funder_nameautrefr_CA
bul.rights.periodeEmbargo0 moisfr_CA
Collection:Articles publiés dans des revues avec comité de lecture

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