Pim-1 : a new biomarker in pulmonary arterial hypertension

Auteur(s): Renard, SébastienPaulin, RoxaneBreuils-Bonnet, SandraSimard, SergePibarot, PhilippeBonnet, SébastienProvencher, Steeve
Résumé: Provirus integration site for Moloney murine leukemia virus (Pim-1) is an oncoprotein overexpressed in lungs from pulmonary arterial hypertension (PAH) patients and involved in cell proliferation via the activation of the NFAT/STAT3 signaling pathway. We hypothesized that Pim-1 plasma levels would predict the presence of PAH and correlate with disease severity. Pim-1 plasma levels were measured at the time of catheterization in 49 PAH patients, including nonvasoreactive (n = 19) and vasoreactive idiopathic PAH (n = 5), and PAH related to connective tissue disease (n = 16) and congenital heart disease (n = 9). Fifty controls were also recruited. The capacity of Pim-1 to discriminate PAH from controls and its association with disease severity were assessed. Pim-1 plasma levels were higher in PAH than in controls (9.6 ± 4.0 vs. 7.2 ± 2.4 ng/mL, P < 0.01). Pim-1 appropriately discriminated proliferative PAH from controls (AUC = 0.78 to 0.94 using ROC curves). Among PAH patients, Pim-1 correlated with traditional markers of PAH severity. The 1-year survival was 97% and 47% for PAH patients with baseline Pim-1 levels lower and higher than 11.1 ng/mL, respectively (HR 11.4 (3.3–39.7); P <0.01). After adjustment for hemodynamic and biochemical variables, Pim-1 levels remained an independent predictor of mortality (P < 0.01). Pim-1 is a promising new biomarker in PAH.
Type de document: Article de recherche
Date de publication: 1 janvier 2013
Date de la mise en libre accès: 28 juin 2016
Version du document: VoR
Lien permanent: http://hdl.handle.net/20.500.11794/7552
Ce document a été publié dans: Pulmonary circulation, Vol. 3 (1), 74-84 (2013)
https://doi.org/10.4103/2045-8932.109917
University of Chicago Press
Autre version disponible: 10.4103/2045-8932.109917
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641743/
Collection :Articles publiés dans des revues avec comité de lecture

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