Bicuspid aortic valve : identifying knowledge gaps and rising to the challenge from the international bicuspid aortic valve consortium (BAVCon)

Authors: Michelena, Hector I.; Prakash, Siddharth K.; Della Corte, Alessandro; Bissell, Malenka M.; Anavekar, Nandan; Mathieu, PatrickBossé, Yohan; Limongelli, Giuseppe; Bossone, Eduardo; Benson, D.Woodrow; Lancellotti, Patrizio; Isselbacher, Eric M.; Enriquez-Sarano, Maurice; Sundt, Thoralf M.; Pibarot, Philippe; Evangelista, Arturo; Milewicz, Dianna M.; Body, Simon C.
Abstract: Since its estimated first description >500 years ago by Leonardo da Vinci, the bicuspid aortic valve (BAV) has progressively built a reputation; initially, as a curious valvular phenotype with a tendency to develop obstruction and insufficiency. In more contemporary times, however, the BAV is recognized as underlying almost 50% of isolated severe aortic stenosis cases requiring surgery, and has been extensively associated with ominous outcomes such as bacterial endocarditis and aortic dissection. These associations, coupled with the high prevalence of BAV in humans, have prompted investigative efforts into the condition, which although insightful, have generated more questions than answers. This review describes our current knowledge of BAV, but, more importantly, it highlights knowledge gaps and areas where basic and clinical research is warranted. Our review has 2 sections. The first section outlines the multifaceted challenge of BAV, our current understanding of the condition, and barriers that may hamper the advancement of the science. The second section proposes a roadmap to discovery based on current imaging, molecular biology, and genetic tools, recognizing their advantages and limitations.
Document Type: Article de recherche
Issue Date: 24 June 2014
Open Access Date: Restricted access
Document version: VoR
This document was published in: Circulation, Vol. 129 (25), 2691-2704 (2014)
American Heart Association
Alternative version: 10.1161/CIRCULATIONAHA.113.007851
Collection:Articles publiés dans des revues avec comité de lecture

Files in this item:
Description SizeFormat 
1.07 MBAdobe PDF    Request a copy
All documents in CorpusUL are protected by Copyright Act of Canada.