Molecular remodeling of adipose tissue is associated with metabolic recovery after weight loss surgery

DC FieldValueLanguage
dc.contributor.authorBouchard-Mercier, Annie-
dc.contributor.authorToro Martín, Juan de-
dc.contributor.authorNadeau, Mélanie-
dc.contributor.authorLescelleur, Odette-
dc.contributor.authorLebel, Stéfane-
dc.contributor.authorRichard, Denis-
dc.contributor.authorBiertho, Laurent-
dc.contributor.authorTchernof, André-
dc.contributor.authorVohl, Marie-Claude-
dc.date.accessioned2022-08-03T19:01:30Z-
dc.date.available2022-08-03T19:01:30Z-
dc.date.issued2022-06-23-
dc.identifier.issn1479-5876fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/74042-
dc.description.abstractBackground Bariatric surgery is an effective therapy for individuals with severe obesity to achieve sustainable weight loss and to reduce comorbidities. Examining the molecular signature of subcutaneous adipose tissue (SAT) following different types of bariatric surgery may help in gaining further insight into their distinct metabolic impact. Results Subjects undergoing biliopancreatic diversion with duodenal switch (BPD-DS) showed a significantly higher percentage of total weight loss than those undergoing gastric bypass or sleeve gastrectomy (RYGB + SG) (41.7 ± 4.6 vs 28.2 ± 6.8%; p = 0.00005). Individuals losing more weight were also significantly more prone to achieve both type 2 diabetes and dyslipidemia remission (OR = 0.75; 95%CI = 0.51–0.91; p = 0.03). Whole transcriptome and methylome profiling showed that bariatric surgery induced a profound molecular remodeling of SAT at 12 months postoperative, mainly through gene down-regulation and hypermethylation. The extent of changes observed was greater following BPD-DS, with 61.1% and 49.8% of up- and down-regulated genes, as well as 85.7% and 70.4% of hyper- and hypomethylated genes being exclusive to this procedure, and mostly associated with a marked decrease of immune and inflammatory responses. Weight loss was strongly associated with genes being simultaneously differentially expressed and methylated in BPD-DS, with the strongest association being observed for GPD1L (r²=0.83; p=1.4x10⁻⁶). Conclusions Present findings point to the greater SAT molecular remodeling following BPD-DS as potentially linked with higher metabolic remission rates. These results will contribute to a better understanding of the metabolic pathways involved in the response to bariatric surgery and will eventually lead to the development of gene targets for the treatment of obesity.fr
dc.languageengfr
dc.publisherSpringer Naturefr
dc.subjectWhole genomefr
dc.subjectTranscriptomicfr
dc.subjectMethylomicfr
dc.subjectObesityfr
dc.subjectBariatric surgeryfr
dc.subjectRemissionfr
dc.subjectType 2 diabetesfr
dc.subjectDyslipidemiafr
dc.subjectSubcutaneous adipose tissuefr
dc.titleMolecular remodeling of adipose tissue is associated with metabolic recovery after weight loss surgeryfr
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationJournal of translational medecine, (2022)fr
dc.identifier.doi10.1186/s12967-022-03485-6fr
dc.subject.rvmObésité -- Chirurgiefr
dc.subject.rvmTissu adipeux -- Aspect moléculairefr
dc.subject.rvmGénome humainfr
dc.subject.rvmTranscriptomiquefr
dc.subject.rvmRémission (Médecine)fr
dc.subject.rvmDiabète non insulinodépendantfr
dc.subject.rvmDyslipidémiesfr
rioxxterms.versionAccepted Manuscriptfr
rioxxterms.version_of_recordhttps://doi.org/10.1186/s12967-022-03485-6fr
rioxxterms.project.funder_nameCanadian Institutes of Health Researchfr
rioxxterms.project.funder_nameJohnson and Johnsonfr
ali.license_refAttribution CC BYfr
ali.license_ref.start_date2022-08-01fr
bul.rights.periodeEmbargo0 moisfr
dc.audience.peerreviewOuifr
Collection:Articles publiés dans des revues avec comité de lecture

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