Rôle des lymphocytes T CD8 exprimant le récepteur CXCR5 au cours de l'infection par le virus de l'immunodéficience simienne chez le Macaque rhésus

Authors: Benmadid, Ghita
Advisor: Estaquier, Jérôme
Abstract: The immune system plays a key part in eradicating the human immunodeficiency virus (HIV). Nevertheless, the persistence of HIV in reservoir organs remains a major public health problem. The germinal centers (GCs) of lymphoid have been shown to be lusters of viral replication. Additionally, some CD8 T cells that express the chemokine receptor CXCR5 can migrate to GCs. Therefore, this specific cell population represents a major interest for the control of HIV in organs such as the spleen, peripheral and mesenteric lymph nodes. In this context, my work has shown that, in Macaque model, during SIV infection, the CD8 CXCR5+ T cells are indeed mainly localized in the lymphoid organs. However, these CD8 CXCR5+ T cells do not express high levels of cytotoxic molecules such as granzymB and perforin. Thus, there are not able to completely eliminate the virus.
Document Type: Mémoire de maîtrise
Issue Date: 2022
Open Access Date: 9 May 2022
Permalink: http://hdl.handle.net/20.500.11794/73367
Grantor: Université Laval
Collection:Thèses et mémoires

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