Épidémiologie de la maladie rénale chronique chez les patients hospitalisés pour une sténose aortique au Québec

Authors: Khelifi, Nada
Advisor: Mac-Way, FabriceJean, SoniaBlais, Claudia
Abstract: Aortic stenosis (AS) is the most prevalent valvular heart disease in developed countries. AS is characterized by progressive fibro-calcific remodelling and thickening of the aortic valve leaflets. In the past years, mineral and bone disorders of chronic kidney disease (CKD) have been identified as key contributors to the development of AS. However, the burden of AS has never been studied in CKD context. Thus, the objective of this master thesis is to describe the temporal trends of AS, according to CKD status and severity, in the Quebec adult population hospitalized for an incident AS, and to compare them to that of a matched control population. We performed a population-based case-control study including 108,780 patients hospitalized for an incident AS and 543,900 age-, sex- and fiscal year-matched patients from 2000 to 2016 in the province of Quebec, Canada. Our results suggested that presence of comorbid CKD is consistently higher in AS compared to non-AS patients. Furthermore, proportion of patients with CKD increased among AS individuals, while it decreased among non AS individuals between 2000 and 2016. These results suggest that AS is closely related to CKD and that these trends likely reflect inadequate risk factor control in this complex population. From a public health perspective, our results are essential for planning the local health needs and guiding future interventions, and there by improving care delivery, as AS and CKD have the potential to become major health issues over the coming years.
Document Type: Mémoire de maîtrise
Issue Date: 2022
Open Access Date: 2 May 2022
Permalink: http://hdl.handle.net/20.500.11794/73292
Grantor: Université Laval
Collection:Thèses et mémoires

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