Angiotensin receptor blockers are associated with reduced fibrosis and interleukin-6 expression in calcific aortic valve disease.

DC FieldValueLanguage
dc.contributor.authorCôté, Nancy-
dc.contributor.authorMahmut, Ablajan-
dc.contributor.authorFournier, Dominique-
dc.contributor.authorBoulanger, Marie-Chloé-
dc.contributor.authorCouture, Christian-
dc.contributor.authorDesprés, Jean-Pierre-
dc.contributor.authorTrahan, Sylvain-
dc.contributor.authorBossé, Yohan-
dc.contributor.authorPagé, Sylvain-
dc.contributor.authorPibarot, Philippe-
dc.contributor.authorMathieu, Patrick-
dc.description.abstractBACKGROUND: Calcific aortic valve disease (CAVD) is a chronic disorder characterized by the mineralization of the aortic valve and involving fibrosis. OBJECTIVES: In this work we sought to determine if the fibrotic component of the remodeling process of CAVD was related to the use of angiotensin-converting enzyme inhibitors (ACEi) and/or angiotensin receptor blockers (ARBs). METHODS: In 477 patients with CAVD, the aortic valve was examined by histology. A semiquantitative score of fibrosis was generated and associations with clinical/cardiometabolic variables examined. In a subset of 103 patients the aortic valve was available to study the infiltration by inflammatory cells and expression of interleukin-6 (IL-6) by quantitative real-time PCR. RESULTS: The fibrosis score of the aortic valve was independently related to the hemodynamic severity of CAVD measured by echocardiography. The fibrotic score of the aortic valve was also related to the expression of IL-6. The use of ARBs but not of ACEi was associated with a lower fibrosis score of the aortic valve even after correction for covariates. In addition, patients under ARBs had lower aortic valve inflammation and expression of IL-6. CONCLUSIONS: These findings suggest that ARBs may alter the fibrotic process of the aortic valve in CAVD, possibly by lowering tissue inflammation.fr_CA
dc.publisherS. Kargerfr_CA
dc.subjectCalcific aortic valve diseasefr_CA
dc.subjectAortic stenosisfr_CA
dc.subjectAngiotensin receptor blockersfr_CA
dc.subjectSmall dense low-density lipoproteinsfr_CA
dc.titleAngiotensin receptor blockers are associated with reduced fibrosis and interleukin-6 expression in calcific aortic valve disease.fr_CA
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherche-
dcterms.bibliographicCitationPathobiology, Vol. 81 (1), 15-24 (2014)fr_CA
dc.audienceProfesseurs (Enseignement supérieur)fr_CA
dc.subject.rvmEnzyme de conversion de l'angiotensine -- Inhibiteursfr_CA
dc.subject.rvmEnzyme de conversion de l'angiotensine -- Récepteursfr_CA
dc.subject.rvmAorte -- Rétrécissementfr_CA
dc.subject.rvmValvule semi-lunaire de l'ostium aortique -- Calcificationfr_CA
dc.subject.rvmCœur -- Fibrosefr_CA
dc.subject.rvmInterleukine 6fr_CA
dc.subject.rvmLipoprotéines de basse densitéfr_CA
rioxxterms.versionVersion of Recordfr_CA
Collection:Articles publiés dans des revues avec comité de lecture

Files in this item:
Description SizeFormat 
1.53 MBAdobe PDF    Request a copy
All documents in CorpusUL are protected by Copyright Act of Canada.