Douleurs thoraciques non-cardiaques chez les patients présentant un trouble anxieux comorbide
|Abstract:||This thesis includes two different studies on patients with noncardiac chest pain (NCCP) and a comorbid anxiety disorder (panic disorder (PD) or generalized anxiety disorder (GAD)). The first study concerns a prospective cohort study that describes and compares NCCP severity and the physical and mental components of health-related quality of life in patients with NCCP, with or without comorbid PD or GAD. A total of 915 patients who visited an emergency department for NCCP were selected from a larger study and observed over a six-month period. A telephone interview was conducted to assess NCCP mean severity following the initial emergency department visit and six months later. The patients also completed a questionnaire on health-related quality of life at both time points. The findings show that the presence of comorbid PD or GAD is associated with increased NCCP severity and lowered health-related quality of life. The impact of PD on NCCP mean severity does not appear to be different from that of GAD. However, PD seems to be mainly associated with a poorer physical quality of life, while GAD seems more associated with a poorer mental quality of life. The results confirm the relevance of specifically assessing components of quality of life since they vary according to the comorbid anxiety disorder and suggest that the interventions for these patients must consider specific aspects of each anxiety disorder. The second study concerns a prospective cohort study that describes and compares NCCP-related disability in patients with NCCP and comorbid PD or GAD following the initial emergency department visit and six months later. This study is also the first to empirically test an explanatory model of NCCP-related disability including different psychological factors (anxiety, anxiety sensitivity, heart-focused anxiety, and alexithymia) with this specific population of patients. A total of 124 patients who visited an emergency department for NCCP and presented with comorbid PD or GAD were selected from a larger study and observed over a six-month period. A telephone interview was conducted with all patients to assess their NCCP-related disability following the initial emergency department visit and six months later. The patients also completed validated self-report questionnaires at baseline to assess the different factors proposed in the explanatory model. The results show a high prevalence of NCCP-related disability in patients with comorbid PD or GAD at both time points. The presence of PD, with or without comorbid GAD, was significantly associated with the presence of NCCP-related disability at the six-month follow-up. Among the factors proposed in the model, heart-focused anxiety is the only psychological factor directly associated with NCCP-related disability in patients with comorbid PD or GAD. Heart-focused anxiety could therefore be considered as an additional treatment target to reduce NCCP-related disability in these patients.|
|Document Type:||Thèse de doctorat|
|Open Access Date:||9 August 2021|
|Collection:||Thèses et mémoires|
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