L'effet de la composition de la diète et de l'activité physique aérobie sur l'axe microbiome intestinal-endocannabinoïdome

Authors: Forteza, Fabiola
Advisor: Raymond, Frédéric
Abstract: The endocannabinoidome is a broad-spectrum biological system, an important actor in the maintenance of homeostatic functions that are regulated by diet and physical activity. The gut microbiota refers to the bacterial flora residing in the gastrointestinal tract, modulated with dietary changes and physical stress. The dynamics between the gut microbiota – or more broadly, the gut microbiome – and the endocannabinoidome offer interesting paths in the promotion of a healthy and active lifestyle as well as in the optimization of performance. As part of the pilot study “Diet influences the immediate response of endocannabinoid mediators to exercise in active women” carried out with ten very active women of 19-32 years of age, the direct response of some members of the endocannabinoidome as a result of maximum course effort corroborates prior data in the domain. In the context of a seven-day controlled Mediterranean diet, these same metabolites increased more strongly than with the Western diet. The effect of the nutritional intervention was minor on the microbial families of the participants of this cohort. The effect of physical activity on the endocannabinoidome and the gut microbiome is reflected in the brain. The literature review “Neurobiological processes induced by aerobic exercise through endocannabinoidome” aimed to deepen the endocannabinoid mechanisms inherent in cognition, mood, neuroinflammation and pain relatively to physical exercise. The exacerbation or control of neuropsychological conditions through the processes of endocannabinoidome and other adjacent neuroactive mediators was also discussed. These manuscripts are part of a limited line of studies addressing the synergy of the endocannabinoidome and gut microbiome in metabolic and mental health and by extension, in performance. This thesis brings together studies on this subject in addition to suggesting more ways to judiciously adjust physical activity and diet while respecting the gut microbiome-endocannabinoidome axis
Document Type: Mémoire de maîtrise
Issue Date: 2021
Open Access Date: 5 July 2021
Permalink: http://hdl.handle.net/20.500.11794/69526
Grantor: Université Laval
Collection:Thèses et mémoires

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