Caractérisation de l'activité antipsoriasique de substances naturelles d'origine végétale

Authors: Bouchard, Corinne
Advisor: Pouliot, RoxaneVoyer, Normand
Abstract: Skin is the largest organ of the human body. Often neglected and taken for granted, this physical envelope can be affected by various diseases or skin disorders. For example, psoriasis is a chronic and inflammatory dermatosis. Yet, this pathology is much more than an unsightly condition; it affects patients' life quality in a disabling way. Despite scientific progress, psoriasis remains an incurable dermatosis. As a result, the development of new antipsoriatic products is an ongoing issue. Inspired by the substantial contribution of natural products in this dermatosis, one molecule in particular caught our attention : the quebecol. This polyphenolic compound has aroused our scientific curiosity because of its antiproliferative and anti-inflammatory properties. However, considering the very low abundance of quebecol in nature, this molecule is produced by chemical synthesis. Thereby, compounds related to this natural product are also studied as a part of this project. This work presents an exceptional pharmacological tool : the autologous psoriatic skin model. Developed using tissue engineering, this model faithfully reflects the characteristics of in vivo psoriatic skin. Considering its great potential, it remains the ultimate model for characterizing the antipsoriatic activity of new chemical entities. The work described in this paper focuses on the antipsoriatic activity evaluation of molecules of plant origin and synthetic origin. In order to deepen the knowledge of these potential candidates, the possibility of investigating their mechanism of action in the pathology of psoriasis is considered. To do so, the in vitro reconstructed lesional skin - a unique and innovative skin tool - was put to contribution.
Document Type: Mémoire de maîtrise
Issue Date: 2019
Open Access Date: 17 May 2021
Grantor: Université Laval
Collection:Thèses et mémoires

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