Biological plausibility for interactions between dietary fat, resveratrol, ACE2 and SARS-CoV illness severity

Auteur(s): Horne, Justine R.; Vohl, Marie-Claude
Résumé: The angiotensin converting enzyme-2 (ACE2) cellular receptor is responsible for the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus impacting the entrance and clearance of the virus. Studies demonstrate that upregulation of ACE2 has a protective effect on SARS-CoV-2 illness severity. Moreover, animal studies demonstrate that dietary intake can modulate ACE2 gene expression and function. A high intake of resveratrol may have a protective role, upregulating ACE2, whereas a high intake of dietary fat may have a detrimental role, downregulating ACE2. As such, we postulate on the biological plausibility of interactions between dietary fat and/or resveratrol and ACE2 gene variations in the modulation of SARS-CoV-2 illness severity. We call to action the research community to test this plausible interaction in a sample of human subjects.
Type de document: Article de recherche
Date de publication: 7 mai 2020
Date de la mise en libre accès: 7 mai 2021
Version du document: AM
Lien permanent: http://hdl.handle.net/20.500.11794/68984
Ce document a été publié dans: American journal of physiology: endocrinology and metabolism, Vol. 318 (5), E830-E833 (2020)
https://doi.org/10.1152/ajpendo.00150.2020
American Physiological Society
Autre version disponible: 10.1152/ajpendo.00150.2020
32310688
Collection :Articles publiés dans des revues avec comité de lecture

Fichier(s) :
TailleFormat 
Horne_2020.docx2.46 MBMicrosoft Word XMLTélécharger
Tous les documents dans CorpusUL sont protégés par la Loi sur le droit d'auteur du Canada.