Biological plausibility for interactions between dietary fat, resveratrol, ACE2 and SARS-CoV illness severity

DC FieldValueLanguage
dc.contributor.authorHorne, Justine R.-
dc.contributor.authorVohl, Marie-Claude-
dc.date.accessioned2021-04-30T15:29:25Z-
dc.date.available2021-05-07T00:00:00Z-
dc.date.issued2020-05-07-
dc.identifier.issn0193-1849fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/68984-
dc.description.abstractThe angiotensin converting enzyme-2 (ACE2) cellular receptor is responsible for the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus impacting the entrance and clearance of the virus. Studies demonstrate that upregulation of ACE2 has a protective effect on SARS-CoV-2 illness severity. Moreover, animal studies demonstrate that dietary intake can modulate ACE2 gene expression and function. A high intake of resveratrol may have a protective role, upregulating ACE2, whereas a high intake of dietary fat may have a detrimental role, downregulating ACE2. As such, we postulate on the biological plausibility of interactions between dietary fat and/or resveratrol and ACE2 gene variations in the modulation of SARS-CoV-2 illness severity. We call to action the research community to test this plausible interaction in a sample of human subjects.fr
dc.languageengfr
dc.publisherAmerican Physiological Societyfr
dc.titleBiological plausibility for interactions between dietary fat, resveratrol, ACE2 and SARS-CoV illness severityfr
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationAmerican journal of physiology: endocrinology and metabolism, Vol. 318 (5), E830-E833 (2020)fr
dc.identifier.doi10.1152/ajpendo.00150.2020fr
dc.identifier.pubmed32310688fr
dc.subject.rvmCoronavirusfr
dc.subject.rvmResvératrolfr
dc.subject.rvmEnzyme de conversion de l'angiotensinefr
dc.subject.rvmAngiotensine IIfr
dc.subject.rvmExpression géniquefr
dc.subject.rvmPathogenèsefr
dc.subject.rvmAlimentationfr
rioxxterms.versionAccepted Manuscriptfr
rioxxterms.version_of_recordhttps://doi.org/10.1152/ajpendo.00150.2020fr
bul.rights.periodeEmbargo12 moisfr
Collection:Articles publiés dans des revues avec comité de lecture

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