Biological plausibility for interactions between dietary fat, resveratrol, ACE2 and SARS-CoV illness severity

Authors: Horne, Justine R.; Vohl, Marie-Claude
Abstract: The angiotensin converting enzyme-2 (ACE2) cellular receptor is responsible for the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus impacting the entrance and clearance of the virus. Studies demonstrate that upregulation of ACE2 has a protective effect on SARS-CoV-2 illness severity. Moreover, animal studies demonstrate that dietary intake can modulate ACE2 gene expression and function. A high intake of resveratrol may have a protective role, upregulating ACE2, whereas a high intake of dietary fat may have a detrimental role, downregulating ACE2. As such, we postulate on the biological plausibility of interactions between dietary fat and/or resveratrol and ACE2 gene variations in the modulation of SARS-CoV-2 illness severity. We call to action the research community to test this plausible interaction in a sample of human subjects.
Document Type: Article de recherche
Issue Date: 7 May 2020
Open Access Date: 7 May 2021
Document version: AM
This document was published in: American journal of physiology: endocrinology and metabolism, Vol. 318 (5), E830-E833 (2020)
American Physiological Society
Alternative version: 10.1152/ajpendo.00150.2020
Collection:Articles publiés dans des revues avec comité de lecture

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