Système électro-optique pour l'optogénétique cardiaque et l'enregistrement d'ECG

Authors: L. Gagnon, Léonard
Advisor: Gosselin, Benoit
Abstract: In the past few years, optogenetics was used in research to replace electrical stimulation of neurons by photo-stimulation. Scientists now search a way to extend optogenetics to cardiac research. Many were able to control the heartbeat of rodents using light. These experiments were conducted using wired and cumbersome equiments with electrocardiogram (ECG) recording using electrodes and photo-stimulation using optical fibers. These systems increase tests subjects stress which can induce measurements errors. This master's thesis describes the design of a device answering this problem. The developed system enables cardiac photostimulation and ECG recording wirelessly with an implant and a low power electronic circuit. The device also includes a real-time algorithm to reduce motion artifacts shown in preliminary testing. Finally, the operation of the prototype is demonstrated during in-vivo experiments.
Document Type: Mémoire de maîtrise
Issue Date: 2020
Open Access Date: 3 February 2021
Grantor: Université Laval
Collection:Thèses et mémoires

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