Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration

Auteur(s): Smith, Eric E.; Duchesne, Simon
Résumé: Introduction: Many consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) initiative, with a focus on cerebral small vessel disease. Methods: Surveys, teleconferences, and an in-person workshop were used to identify gaps in knowledge and to develop tools for harmonizing imaging and analysis. Results: A framework for neuroimaging biomarker development was developed based on validating repeatability and reproducibility, biological principles, and feasibility of implementation. The status of current MRI biomarkers was reviewed. A website was created at www.harness-neuroimaging.org with acquisition protocols, a software database, rating scales and case report forms, and a deidentified MRI repository. Conclusions: The HARNESS initiative provides resources to reduce variability in measurement in MRI studies of cerebral small vessel disease.
Type de document: Article de recherche
Date de publication: 25 février 2019
Date de la mise en libre accès: 3 novembre 2020
Version du document: VoR
Licence Creative Commons: https://creativecommons.org/licenses/by-nc-nd/4.0
Lien permanent: http://hdl.handle.net/20.500.11794/67088
Ce document a été publié dans: Alzheimer's and dementia, Vol. 11 (1), 191-204 (2019)
https://doi.org/10.1016/j.dadm.2019.01.002
Elsevier
Autre version disponible: 10.1016/j.dadm.2019.01.002
30859119
Collection :Articles publiés dans des revues avec comité de lecture

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