Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration

DC FieldValueLanguage
dc.contributor.authorSmith, Eric E.-
dc.contributor.authorDuchesne, Simon-
dc.date.accessioned2020-11-03T03:35:43Z-
dc.date.available2020-11-03T03:35:43Z-
dc.date.issued2019-02-25-
dc.identifier.issn1552-5260fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/67088-
dc.description.abstractIntroduction: Many consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) initiative, with a focus on cerebral small vessel disease. Methods: Surveys, teleconferences, and an in-person workshop were used to identify gaps in knowledge and to develop tools for harmonizing imaging and analysis. Results: A framework for neuroimaging biomarker development was developed based on validating repeatability and reproducibility, biological principles, and feasibility of implementation. The status of current MRI biomarkers was reviewed. A website was created at www.harness-neuroimaging.org with acquisition protocols, a software database, rating scales and case report forms, and a deidentified MRI repository. Conclusions: The HARNESS initiative provides resources to reduce variability in measurement in MRI studies of cerebral small vessel disease.fr
dc.languageengfr
dc.publisherElsevierfr
dc.subjectCerebrovascular diseasefr
dc.subjectStrokefr
dc.subjectDementiafr
dc.subjectMagnetic resonance imagingfr
dc.subjectRadiologyfr
dc.titleHarmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegenerationfr
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationAlzheimer's and dementia, Vol. 11 (1), 191-204 (2019)fr
dc.identifier.doi10.1016/j.dadm.2019.01.002fr
dc.identifier.pubmed30859119fr
dc.subject.rvmNeuro-imageriefr
dc.subject.rvmAccidents vasculaires cérébrauxfr
dc.subject.rvmImagerie médicale -- Bases de donnéesfr
dc.subject.rvmMarqueurs biologiquesfr
rioxxterms.versionVersion of Recordfr
rioxxterms.version_of_recordhttps://doi.org/10.1016/j.dadm.2019.01.002fr
rioxxterms.project.funder_nameEuropean Unionfr
ali.license_refAttribution - Pas d'Utilisation Commerciale - Pas de Modification CC BY-NC-NDfr
ali.license_ref.start_date2020-10-29fr
bul.rights.periodeEmbargo0 moisfr
dc.audience.peerreviewOuifr
Collection:Articles publiés dans des revues avec comité de lecture

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