Brain atrophy and patch-based grading in individuals from the CIMA-Q study : a progressive continuum from subjective cognitive decline to AD

Authors: Marcotte, Christine; Potvin, OlivierDuchesne, Simon
Abstract: It has been proposed that individuals developing Alzheimer’s disease (AD) first experience a phase expressing subjective complaints of cognitive decline (SCD) without objective cognitive impairment. Using magnetic resonance imaging (MRI), our objective was to verify whether SNIPE probability grading, a new MRI analysis technique, would distinguish between clinical dementia stage of AD: Cognitively healthy controls without complaint (CH), SCD, mild cognitive impairment, and AD. SNIPE score in the hippocampus and entorhinal cortex was applied to anatomical T1-weighted MRI of 143 participants from the Consortium pour l’identification précoce de la maladie Alzheimer - Québec (CIMA-Q) study and compared to standard atrophy measures (volumes and cortical thicknesses). Compared to standard atrophy measures, SNIPE score appeared more sensitive to differentiate clinical AD since differences between groups reached a higher level of significance and larger effect sizes. However, no significant difference was observed between SCD and CH groups. Combining both types of measures did not improve between-group differences. Further studies using a combination of biomarkers beyond anatomical MRI might be needed to identify individuals with SCD who are on the beginning of the clinical continuum of AD.
Document Type: Article de recherche
Issue Date: 19 September 2019
Open Access Date: 26 October 2020
Document version: VoR
Creative Commons Licence: https://creativecommons.org/licenses/by/4.0
Permalink: http://hdl.handle.net/20.500.11794/67013
This document was published in: Scientific Reports, Vol. 9 (1), 1-10 (2019)
https://doi.org/10.1038/s41598-019-49914-3
Nature Publishing Group
Alternative version: 10.1038/s41598-019-49914-3
Collection:Articles publiés dans des revues avec comité de lecture

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