Directing hMSCs fate through geometrical cues and mimetics peptides

DC FieldValueLanguage
dc.contributor.authorPadiolleau, Laurence-
dc.contributor.authorLaroche, Gaétan-
dc.description.abstractThe native microenvironment of mesenchymal stem cells (hMSCs)—the extracellular matrix (ECM), is a complex and heterogenous environment structured at different scales. The present study aims at mimicking the hierarchical microorganization of proteins or growth factors within the ECM using the photolithography technique. Polyethylene terephthalate substrates were used as a model material to geometrically defined regions of RGD + BMP‐2 or RDG + OGP mimetic peptides. These ECM‐derived ligands are under research for regulation of mesenchymal stem cells osteogenic differentiation in a synergic manner. The hMSCs osteogenic differentiation was significantly affected by the spatial distribution of dually grafted peptides on surfaces, and hMSCs cells reacted differently according to the shape and size of peptide micropatterns. Our study demonstrates the presence of a strong interplay between peptide geometric cues and stem cell differentiation toward the osteoblastic lineage. These tethered surfaces provide valuable tools to investigate stem cell fate mechanisms regulated by multiple ECM cues, thereby contributing to the design of new biomaterials and improving hMSCs differentiation
dc.publisherJohn Wiley & Sonsfr
dc.subjectCell differentiationfr
dc.subjectCell-surface interactionfr
dc.subjectHuman mesenchymal stem cellsfr
dc.subjectSurface patterningfr
dc.titleDirecting hMSCs fate through geometrical cues and mimetics peptidesfr
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationJournal of biomedical materials research. Part A, Vol. 108 (2), 201-211 (2020)fr
dc.subject.rvmCellules souches mésenchymateusesfr
dc.subject.rvmSubstance fondamentale (Histologie)fr
dc.subject.rvmFacteurs de croissancefr
dc.subject.rvmPolyéthylène téréphtalatefr
dc.subject.rvmCellules -- Différenciationfr
dc.subject.rvmChimie biomimétiquefr
rioxxterms.versionAccepted Manuscriptfr
rioxxterms.project.funder_nameAgence Nationale de la Recherchefr
rioxxterms.project.funder_nameNational Science and Engineering Research Council of Canadafr
bul.rights.periodeEmbargo12 moisfr
Collection:Articles publiés dans des revues avec comité de lecture

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