Cardiorespiratory effects of hemic versus nonhemic prime during and immediately following mitral valve replacement in dogs

Authors: Pibarot, Philippe; Lanthier, Thérèse; Durand, Louis-Gilles; Langlois, Yves; Lussier, Bertrand; Coppens, Paul
Abstract: In order to limit the hemodilution effect during cardiopulmonary bypass (CPB) in low weight animal patients, blood is often used as a component of the prime solution. This study was undertaken to evaluate the effects of the addition of blood to the prime solution on the hemodynamic and respiratory parameters during and following mitral valve replacement in dogs. Ten dogs were randomly assigned to receive either a hemic (HP), 75% blood component, or a nonhemic prime (NP) solution. The hemodilution was 5 +/- 4% and 25 +/- 10% for the HP and NP groups, respectively. Cardiopulmonary measurements were taken 20 minutes before initiating CPB, during CPB, and 20 min after termination. The hematocrit level, the hemoglobin concentration, and the arterial oxygen content were significantly lower in the NP group during and following CPB. However, the systemic oxygen transport index was not significantly different between the NP group (355 +/- 87 mL/min/m2) and the HP group (546 +/- 155 mL/min/m2) following CPB. Our study indicates that, in normal dogs undergoing hemodilution from a nonhemic prime solution, the cardiovascular function is able to maintain the systemic oxygen transport in the period immediately following mitral valve replacement.
Document Type: Article de recherche
Issue Date: 1 July 1995
Open Access Date: 14 June 2016
Document version: VoR
This document was published in: Canadian journal of veterinary research, Vol. 59 (3), 222-228 (1995)
Canadian Veterinary Medical Association
Alternative version: PMC1263769
Collection:Articles publiés dans des revues avec comité de lecture

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