A new, simple, and accurate method for non-invasive estimation of pulmonary arterial pressure

Authors: Sun, Jingping; Durand, Louis-Gilles; Pibarot, Philippe
Abstract: Objective : To develop and validate a new non-invasive method for the estimation of pulmonary arterial pressure (PAP) based on advanced signal processing of the second heart sound. Design : Prospective comparative study. Setting : Referral cardiology centre. Patients : This method was first tested in 16 pigs with experimentally induced pulmonary hypertension and then in 23 patients undergoing pulmonary artery catheterisation. Methods : The heart sounds were recorded at the surface of the thorax using a microphone connected to a personal computer. The splitting time interval between the aortic and the pulmonary components of the second heart sound was measured using a computer assisted spectral dechirping method and was normalised for heart rate. Results : The systolic PAP varied between 14–73 mm Hg in pigs and between 20–70 mm Hg in patients. The normalised splitting interval was measurable in 97% of the recordings made in pigs and 91% of the recordings made in patients. There was a strong relation between the normalised splitting interval and the systolic PAP (pigs: r = 0.94, standard error of the estimate (SEE) = 5.3 mm Hg; patients: r = 0.84, SEE = 7.8 mm Hg) or the mean pulmonary pressure (pigs: r = 0.94, SEE = 4.1 mm Hg; patients: r = 0.85, SEE = 5.8 mm Hg). Conclusions : This study shows that this new non-invasive method based on advanced signal processing of the second heart sound provides an accurate estimation of the PAP.
Document Type: Article de recherche
Issue Date: 1 July 2002
Open Access Date: Restricted access
Document version: VoR
Permalink: http://hdl.handle.net/20.500.11794/5388
This document was published in: Heart, Vol. 88 (1), 76-80 (2002)
BMJ Publishing Group
Alternative version: 10.1136/heart.88.1.76
Collection:Articles publiés dans des revues avec comité de lecture

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