Impact of prosthesis-patient mismatch on long-term survival after aortic valve replacement : influence of age, obesity, and left ventricular dysfunction

Authors: Mohty, Dania; Dumesnil, Jean G.; Echahidi, Najmeddine; Mathieu, PatrickDagenais, FrançoisVoisine, PierrePibarot, Philippe
Abstract: Objectives : This study was designed to evaluate the effect of valve prosthesis-patient mismatch (PPM) on late survival after aortic valve replacement (AVR) and to determine if this effect is modulated by patient age, body mass index (BMI), and pre-operative left ventricular (LV) function. Background : We recently reported that PPM is an independent predictor of operative mortality after AVR, particularly when associated with LV dysfunction. Methods : The indexed valve effective orifice area (EOA) was estimated in 2,576 patients having survived AVR and was used to define PPM as not clinically significant if it was 0.85 cm2/m2, as moderate if 0.65 and 0.85 cm2/m2, and severe if 0.65 cm2/m2. Results : After adjustment for other risk factors, severe PPM was associated with increased late overall mortality (hazard ratio [HR]: 1.38; p 0.03) and cardiovascular mortality (HR: 1.63; p 0.0006) in the whole cohort. Severe PPM was also associated with increased overall mortality in patients 70 years old (HR: 1.77; p 0.002) and in patients with a BMI 30 kg/m2 (HR: 2.1; p 0.006), but had no impact in older patients or in obese patients. Moderate PPM was a predictor of mortality in patients with LV ejection fraction 50% (HR: 1.21; p 0.01), but not in patients with preserved LV function. Conclusions : Moderate PPM is associated with increased late mortality in patients with LV dysfunction, but with normal prognosis in those with preserved LV function. Notwithstanding the previously demonstrated deleterious effect of severe PPM on early mortality, this factor appears to increase late mortality only in patients 70 years old and/or with a BMI 30 kg/m2 or an LV ejection fraction 50%. (J Am Coll Cardiol 2009;53:39–47) © 2009 by the American College of Cardiology Foundation
Document Type: Article de recherche
Issue Date: 6 January 2009
Open Access Date: Restricted access
Document version: VoR
This document was published in: Journal of the American College of Cardiology, Vol. 53, (1), 39-47 (2009)
Elsevier Inc.
Alternative version: 10.1016/j.jacc.2008.09.022
Collection:Articles publiés dans des revues avec comité de lecture

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