New concepts in valvular hemodynamics : implications for diagnosis and treatment of aortic stenosis

Authors: Pibarot, PhilippeDumesnil, Jean G.
Other Title(s): De nouveaux concepts en hémodynamique valvulaire : les répercussions pour le diagnostic et le traitement de la sténose aortique
Abstract: Aortic valve stenosis (AS) is the third-most frequent heart disease after coronary artery disease and arterial hypertension, and it is associated with a high incidence of adverse outcomes. Recent data support the notion that AS is not an isolated disease uniquely limited to the valve. Indeed, AS is frequently associated with abnormalities of the systemic arterial system, and, in particular, with reduced arterial compliance, which may have important consequences for the pathophysiology and clinical outcome of this disease. Moreover, AS may also be associated with left ventricular systolic dysfunction and reduced transvalvular flow rate, which pose important challenges with regards to diagnostic evaluation and clinical decision making in AS patients. Hence, the assessment of AS severity, as well as its therapeutic management, should be conducted with the use of a comprehensive evaluation that includes not only the aortic valve, but also the systemic arterial system and the left ventricle because these three entities are tightly coupled from both a pathophysiological and a hemodynamic standpoint.
Document Type: Article de recherche
Issue Date: 1 October 2007
Open Access Date: Restricted access
Document version: VoR
Permalink: http://hdl.handle.net/20.500.11794/4628
This document was published in: The Canadian journal of cardiology, Vol 23 (supplement B), 40B-47B (2007)
https://doi.org/10.1016/S0828-282X(07)71009-7
Canadian Cardiology Publications
Alternative version: 10.1016/S0828-282X(07)71009-7
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794462/
Collection:Articles publiés dans des revues avec comité de lecture

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