Host–microbe interplay in the cardiometabolic benefits of dietary polyphenols

Authors: Anhê, Fernando Forato; Choi, Béatrice; Dyck, Jason; Schertzer, Jonathan; Marette, André
Abstract: Polyphenols are nonessential phytonutrients abundantly found in fruits and vegetables. A wealth of data from preclinical models and clinical trials consistently supports cardiometabolic benefits associated with dietary polyphenols in murine models and humans. Furthermore, a growing number of studies have shown that specific classes of polyphenols, such as proanthocyanidins (PACs) and ellagitannins, as well as the stilbenoid resveratrol, can alleviate several features of the metabolic syndrome. Moreover, mounting evidence points to the gut microbiota as a key mediator of the health benefits of polyphenols. In this review we summarize recent findings supporting the beneficial potential of polyphenols against cardiometabolic diseases, with a focus on the role of host-microbe interactions.
Document Type: Article de recherche
Issue Date: 7 May 2019
Open Access Date: 17 July 2020
Document version: AM
This document was published in: Trends in Endocrinology and Metabolism, Vol. 30 (6), 384-395 (2019)
Elsevier Science
Alternative version: 10.1016/j.tem.2019.04.002
Collection:Articles publiés dans des revues avec comité de lecture

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