Effets de fractions d'écorce de cannelle sur Candida albicans et les cellules épithéliales buccales

Authors: Veilleux, Marie-Pier
Advisor: Grenier, Daniel
Abstract: Candida albicans is an opportunistic pathogenic fungus associated with superficial and systemic infections, particularly in immunologically or medically compromised individuals. C. albicans is particularly responsible for oral candidiasis and denture stomatitis. In addition, ulcerative oral lesions (oral mucositis) resulting from chemotherapy and radiotherapy treatments are susceptible to secondary infections by C. albicans. This fungus has a multitude of virulence factors allowing it to colonize the host, to counteract the defenses of the immune system and to induce an inflammatory response. Currently treated with antifungals such as nystatin and fluconazole, candidiasis infections are increasingly difficult to cure, due to the increased resistance of the pathogen to these molecules. The purpose of the research project was to evaluate the effects of cinnamon essential oil and proanthocyanidins on the growth and major virulence factors of C. albicans. Moreover, the effect of the same compounds on oral epithelial cells was investigated.
Document Type: Mémoire de maîtrise
Issue Date: 2019
Open Access Date: 23 January 2020
Permalink: http://hdl.handle.net/20.500.11794/37895
Grantor: Université Laval
Collection:Thèses et mémoires

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