Effects of progesterone at the enteric level in a mouse model of Parkinson's disease
|Advisor:||Di Paolo, Thérèse; Soulet, Denis|
|Abstract:||Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world. It is characterized by motor symptoms caused by the loss of dopaminergic neurons in the brain’s substantia nigra. Patients also suffer from nonmotor symptoms that can appear many years before motor symptoms. Among them are gastrointestinal problems, which suggest the implication of the enteric nervous system (ENS) in the pathology. Indeed, dopaminergic neurons are found in the myenteric plexus (MP) of the SNE, of which one role is the regulation of the gut’s motility. Moreover, increased inflammation can be observed in patients. The incidence of PD is higher in men than in women, suggesting a beneficial effect from female hormones. Progesterone was shown to be neuroprotective in traumatic brain injuries, as well as in the central nervous system of PD animal models. Having not been studied at the enteric level in PD models, the objective of this project was thus to evaluate progesterone’s effects in the MP of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-lesioned mice, a neurotoxin that model the disease. Different doses of progesterone (0.4, 8, 16 mg/kg) were also administered and results were obtained by immunohistochemistry and immunofluorescence experiments on the MP of the ileum. Our results showed neuroprotective and antiinflammatory effects of progesterone in the mice’s ENS. Since only symptomatic treatments are currently available for PD, this study proves relevant for the eventual development of neuroprotective therapies.|
|Document Type:||Mémoire de maîtrise|
|Open Access Date:||8 January 2020|
|Collection:||Thèses et mémoires|
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