Gallium(III) triflate catalyzed diastereoselective mukaiyama aldol reaction by using low catalyst loadings

Authors: Plancq, Baptiste; Justafort, Lyse Carole; Lafantaisie, Mathieu; Ollevier, Thierry
Abstract: A mild method for the diastereoselective Mukaiyama aldol reaction is reported. By using a low loading of the gallium(III) triflate catalyst (down to 0.01 mol-%), the transformation proceeds efficiently to afford the corresponding ß-hydroxy ketones in yields up to 92¿%. To the best of our knowledge, this is the first report of a metal triflate acting as a safe, bench-stable, and slow-releasing source of triflic acid for the Mukaiyama aldol reaction.
Document Type: Article de recherche
Issue Date: 5 September 2013
Open Access Date: 16 March 2016
Document version: AM
This document was published in: European journal of organic chemistry, Vol. 2013 (29), 6525–6529 (2013)
Alternative version: 10.1002/ejoc.201301100
Collection:Articles publiés dans des revues avec comité de lecture

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