The Canadian dementia imaging protocol : harmonization validity for morphometry measurements

Authors: Potvin, OlivierChouinard, IsabelleDieumegarde, Louis; Bartha, Robert; Bellec, Pierre; Collins, D. Louis; Descoteaux, Maxime; Hoge, Rick; Ramirez, Joel; Scott, Christopher J.M.; Smith, Eric E.; Strother, S. C.; Black, Sandra E.; Duchesne, Simon
Abstract: The harmonized Canadian Dementia Imaging Protocol (CDIP) has been developed to suit the needs of a number of co-occurring Canadian studies collecting data on brain changes across adulthood and neurodegeneration. In this study, we verify the impact of CDIP parameters compliance on total brain volume variance using 86 scans of the same individual acquired on various scanners. Data included planned data collection acquired within the Consortium pour l’identification précoce de la maladie Alzheimer - Québec (CIMA-Q) and Canadian Consortium on Neurodegeneration in Aging (CCNA) studies, as well as opportunistic data collection from various protocols. For images acquired from Philips scanners, lower variance in brain volumes were observed when the stated CDIP resolution was set. For images acquired from GE scanners, lower variance in brain volumes were noticed when TE/TR values were within 5% of the CDIP protocol, compared to values farther from that criteria. Together, these results suggest that a harmonized protocol like the CDIP may help to reduce neuromorphometric measurement variability in multicentric studies.
Document Type: Article de recherche
Issue Date: 18 July 2019
Open Access Date: 6 August 2019
Document version: AM
This document was published in: NeuroImage: Clinical, 101943 (2019)
Elsevier BV
Alternative version: 10.1016/j.nicl.2019.101943
Collection:Articles publiés dans des revues avec comité de lecture

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