Fibrous composite material for textile heart valve design : in vitro assessment

Authors: Laroche, Gaétan; Amri, Amna; Heim, Frederic; Laroche, Gaétan
Abstract: With over 150,000 implantations performed over the world, transcatheter aortic valve replacement (TAVR) has become a surgical technique, which largely competes with open surgery valve replacement for an increasing number of patients. The success of the procedure favors the research toward synthetic valve leaflet materials as an alternative to biological tissues, whose durability remains unknown. In particular, fibrous constructions have recently proven to be durable in vivo over a 6-month period of time in animal sheep models. Exaggerated fibrotic tissue formation remains, however, a critical issue to be addressed. This work investigates the design of a composite fibrous construction combining a woven polyethylene terephthalate (PET) layer and a non-woven PET mat, which are expected to provide, respectively, strength and appropriate topography toward limited fibrotic tissue ingrowth. For this purpose, a specific equipment has been developed to produce non-woven PET mats made from fibers with small diameter. These mats were assembled with woven PET substrates using various assembling techniques in order to obtain hybrid fibrous constructions. The physical and mechanical properties of the obtained materials were assessed and valve samples were manufactured to be tested in vitro for hydrodynamic performances. The results show that the composite fibrous construction is characterized by properties suitable for the valve leaflet function, but the durability of the assembling is however limited under accelerated cyclic loading.
Document Type: Article de recherche
Issue Date: 17 April 2018
Open Access Date: 23 July 2019
Document version: AM
Permalink: http://hdl.handle.net/20.500.11794/35603
This document was published in: Biomedical Engineering, Vol. 63 (3), 221 (2018)
https://doi.org/10.1515/bmt-2017-0226
Alternative version: 10.1515/bmt-2017-0226
29664732
Collection:Articles publiés dans des revues avec comité de lecture

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