Atmospheric pressure plasma polymer of ethyl lactate: In vitro degradation and cell viability studies

Authors: Laurent, Morgane; Koehler, Julia; Sabbatier, Gad; Hoesli, Corinne A.; Ghérardi, Nicolas; Laroche, Gaétan
Abstract: Ethyl lactate is injected into a dielectric barrier discharge (DBD) to build up a degradable plasma polymer (PP) to be used as a drug delivery system. Plasma power, deposition time, and type of carrier gas (Ar, N2) are correlated to the coating in vitro degradation rate. PPs are characterized by AFM, SEM, IR spectroscopy, XPS, and SEC, while surface profilometry is used to monitor the degradation kinetics. PPs deposited under N2 are mainly composed of hydrophilic functionalities, which explain their fast degradation upon exposure to an aqueous environment. In contrast, PPs synthesized under Ar lead to a slower degradation rate due to their hydrocarbon structure containing some hydrolyzable moieties. The potential of the PPs for vascular applications is verified
Document Type: Article de recherche
Issue Date: 29 March 2016
Open Access Date: Restricted access
Document version: AM
Permalink: http://hdl.handle.net/20.500.11794/35600
This document was published in: Plasma processes and polymers, Vol. 13 (7), 711–721 (2016)
https://doi.org/10.1002/ppap.201500211
Wiley
Alternative version: 10.1002/ppap.201500211
Collection:Articles publiés dans des revues avec comité de lecture

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