Synthesis ofiImidazolidinone, imidazolone, and Benzimidazolone Derivatives through oxidation using copper and air

Authors: Li, DazhiOllevier, Thierry
Abstract: A new synthetic method of urea derivatives using copper and air was developed. These mild conditions provided moderate to very good yields for 15 examples (53–93%), while low yields were obtained with sterically hindered substrates (3 examples). The reaction was found to go through an in situ-generated copper-N-heterocyclic carbene, which is then oxidized into cyclic urea derivatives possessing alkyl, benzyl, aryl, hydroxy, Boc-protected, and tertiary amine groups
Document Type: Article de recherche
Issue Date: 6 May 2019
Open Access Date: 6 May 2020
Document version: AM
This document was published in: Organic letters : Article ASAP, S-1-S-95 (2019)
American Chemical Society
Alternative version: 10.1021/acs.orglett.9b00973
Collection:Articles publiés dans des revues avec comité de lecture

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