Conception d'un dispositif expérimental pour la mise à l'essai in vitro et ex vivo d'un pancréas bioartificiel

Authors: Gauvin-Rossignol, Gabrielle
Advisor: Bégin-Drolet, AndréRuel, Jean
Abstract: Type 1 diabetes, an immune system dysfunction that causes the attack of insulin secretory cells, is the subject of many scientific researches because of its significant negative impact on the world’s population health. Bégin- Drolet, Ruel and Hoesli research groups use the 3D printing technology of sugar fugitive ink to build embedded vascular networks in hydrogel scaffolds seeded with insulin secretory cells. Cells encapsulation in hydrogel allows them to be isolated from the immune system and provides a tridimensional support structure that mimic the natural extracellular matrix. Vascular channels resulting from the rapid casting of fugitive inks, allows adequate perfusion of nutrients supply to encapsulated cells, and transportation of metabolic wastes and secreted insulin they produce. The aim of this project, presented in this thesis, consists in designing a device to test this approach by ex vivo and in vitro experiments. The device is the proof of concept that the method of sacrificial ink molding of cell seeded hydrogel scaffolds is effective and promising for the construction of a vascularized bioartificial pancreas.
Document Type: Mémoire de maîtrise
Issue Date: 2019
Open Access Date: 24 April 2019
Grantor: Université Laval
Collection:Thèses et mémoires

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