Impact de l'inflammation sur la rigidité aortique en insuffisance rénale chronique
|Abstract:||Cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease (CKD). Studies have shown an association between aortic stiffness, a nontraditional risk factor, and high mortality rate in CKD patients. Aortic stiffness has always been considered as a non-inflammatory vascular disease. However, recently, using a CKD animal model with pure medial vascular calcification, we have shown an increase expression of interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumour necrosis factor (TNF) in calcified aortic wall. Therefore, we hypothesized that inflammation might be involved in the physiopathology of aortic stiffness in CKD patients. The aims of this master are 1) to study the impact of IL-1β, IL-6 and TNF on aortic stiffness in CKD patients undergoing dialysis, 2) to examine the effect of the activation of the immune system on the evolution of aortic stiffness after a kidney transplantation (KTx) and 3) to evaluate the impact of angiopoietin-like-2 (ANGPTL2), a novel inflammatory biomarker of vascular aging, on aortic stiffness after KTx. According to our results, the activation of the immune system seems to play a key role in the physiopathology of aortic stiffness. Indeed, IL-6, a pro-inflammatory cytokine, is associated with aortic stiffness in CKD patients undergoing dialysis. Also, increase levels of IL-6 three months after KTx is associated with an unfavourable evolution of aortic stiffness after KTx, suggesting that IL-6 is involved in arterial walls remodeling in kidney transplant recipients. In addition, ANGPTL2 is associated with aortic stiffness and mortality in kidney transplant recipients, suggesting that ANGPTL2 may play a biological role in CKD-related-CVD. Our results suggest that inflammation may represent a novel therapeutic target of CKD-related-CVD.|
|Document Type:||Mémoire de maîtrise|
|Open Access Date:||18 April 2019|
|Collection:||Thèses et mémoires|
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