Transition-metal-free a-arylation of enolizable aryl ketones and mechanistic evidence for a radical process
| Authors: | Drapeau, Martin Pichette; Fabre, Indira; Grimaud, Laurence; Ciofini, Ilaria; Ollevier, Thierry; Taillefer, Marc |
| Abstract: | The a-arylation of enolizable aryl ketones can be carried out with aryl halides under transition-metal-free conditions using KOtBu in DMF. The a-aryl ketones thus obtained can be used for step- and cost-economic syntheses of fused heterocycles and Tamoxifen. Mechanistic studies demonstrate the synergetic role of base and solvent for the initiation of the radical process. |
| Document Type: | Article de recherche |
| Issue Date: | 1 July 2015 |
| Open Access Date: | 16 March 2016 |
| Document version: | AM |
| Permalink: | http://hdl.handle.net/20.500.11794/343 |
| This document was published in: | Angewandte Chemie International Edition, Vol. 54 (36), 10587–10591 (2015) https://doi.org/10.1002/anie.201502332 John Wiley & Sons, Inc. |
| Alternative version: | 10.1002/anie.201502332 |
| Collection: | Articles publiés dans des revues avec comité de lecture |
Files in this item:
| Description | Size | Format | ||
|---|---|---|---|---|
| Alpha-arylation ACIE versionacceptee.pdf | 659.36 kB | Adobe PDF | View/Open | |
| anie_201502332_sm_miscellaneous_information.pdf | Données supplémentaires | 3.07 MB | Adobe PDF | Request a copy |
| 2015ACIE10587.pdf | Version of Record | 901.46 kB | Adobe PDF | Request a copy |
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