Hypothesis : a role for fragile XMental retardation protein in mediating and relieving microRNA-guided translational repression?

DC FieldValueLanguage
dc.contributor.authorPlante, Isabelle-
dc.contributor.authorProvost, Patrick-
dc.date.accessioned2019-04-04T19:35:18Z-
dc.date.available2019-04-04T19:35:18Z-
dc.date.issued2006-08-01-
dc.identifier.issn1110-7243fr
dc.identifier.urihttp://hdl.handle.net/20.500.11794/34288-
dc.description.abstractMicroRNA (miRNA)-guided messenger RNA (mRNA) translational repression is believed to be mediated by effector miRNA-containing ribonucleoprotein (miRNP) complexes harboring fragile X mental retardation protein (FMRP). Recent studies documented the nucleic acid chaperone properties of FMRP and characterized its role and importance in RNA silencing in mammalian cells. We propose a model in which FMRP could facilitate miRNA assembly on target mRNAs in a process involving recognition of G quartet structures. Functioning within a duplex miRNP, FMRP may also mediate mRNA targeting through a strand exchange mechanism, in which the miRNA* of the duplex is swapped for the mRNA. Furthermore, FMRP may contribute to the relief of miRNA-guided mRNA repression through a reverse strand exchange reaction, possibly initiated by a specific cellular signal, that would liberate the mRNA for translation. Suboptimal utilization of miRNAs may thus account for some of themolecular defects in patients with the fragile X syndrome.fr
dc.languageengfr
dc.publisherHindawifr
dc.titleHypothesis : a role for fragile XMental retardation protein in mediating and relieving microRNA-guided translational repression?fr
dc.typeCOAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherchefr
dcterms.bibliographicCitationJournal of Biomedicine and Biotechnology, Vol. 2006 (4), (2006)fr
dc.identifier.doi10.1155/JBB/2006/16806.fr
dc.identifier.pubmed17057359fr
dc.subject.rvmMicroARNfr
dc.subject.rvmARN messagerfr
dc.subject.rvmSyndrome de l'X fragile -- Aspect génétiquefr
dc.subject.rvmRibonucléoprotéinesfr
dc.subject.rvmInactivation géniquefr
dcterms.date.accepted2006-05-02-
rioxxterms.versionVersion of Recordfr
rioxxterms.version_of_recordhttps://doi.org/10.1155/JBB/2006/16806fr
rioxxterms.project.funder_nameCanadian Institutes of Health Researchfr
bul.rights.periodeEmbargo0 moisfr
Collection:Articles publiés dans des revues avec comité de lecture

Files in this item:
Description SizeFormat 
3 Plante Hyp FMRP JBB 2006 16806 copy.pdf913.44 kBAdobe PDFThumbnail
View/Open
All documents in CorpusUL are protected by Copyright Act of Canada.