Hypothesis : a role for fragile XMental retardation protein in mediating and relieving microRNA-guided translational repression?

Authors: Plante, IsabelleProvost, Patrick
Abstract: MicroRNA (miRNA)-guided messenger RNA (mRNA) translational repression is believed to be mediated by effector miRNA-containing ribonucleoprotein (miRNP) complexes harboring fragile X mental retardation protein (FMRP). Recent studies documented the nucleic acid chaperone properties of FMRP and characterized its role and importance in RNA silencing in mammalian cells. We propose a model in which FMRP could facilitate miRNA assembly on target mRNAs in a process involving recognition of G quartet structures. Functioning within a duplex miRNP, FMRP may also mediate mRNA targeting through a strand exchange mechanism, in which the miRNA* of the duplex is swapped for the mRNA. Furthermore, FMRP may contribute to the relief of miRNA-guided mRNA repression through a reverse strand exchange reaction, possibly initiated by a specific cellular signal, that would liberate the mRNA for translation. Suboptimal utilization of miRNAs may thus account for some of themolecular defects in patients with the fragile X syndrome.
Document Type: Article de recherche
Issue Date: 1 August 2006
Open Access Date: 4 April 2019
Document version: VoR
Permalink: http://hdl.handle.net/20.500.11794/34288
This document was published in: Journal of Biomedicine and Biotechnology, Vol. 2006 (4), (2006)
Alternative version: 10.1155/JBB/2006/16806.
Collection:Articles publiés dans des revues avec comité de lecture

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