Regulatory RNAs : future perspectives in diagnosis, prognosis, and individualized therapy

DC FieldValueLanguage
dc.contributor.authorPerron, Marjorie-
dc.contributor.authorBoissonneault, Vincent-
dc.contributor.authorGobeil, Lise-Andrée-
dc.contributor.authorOuellet, Dominique-
dc.contributor.authorProvost, Patrick-
dc.description.abstractWith potentially up to 1000 microRNAs (miRNAs) present in the human genome, altogether regulating the expression of thousands of genes, one can anticipate that miRNAs will play a significant role in health and disease. Deregulated protein expression induced by a dysfunctional miRNA-based regulatory system is thus expected to lead to the development of serious, if not lethal, genetic diseases. A relationship among miRNAs, Dicer, and cancer has recently been suggested. Further investigations will help establish specific causal links between dysfunctional miRNAs and diseases. miRNAs of foreign origin, e.g., viruses, may also be used as specific markers of viral infections. In these cases, miRNA expression profiles could represent a powerful diagnostic tool. Regulatory RNAs may also have therapeutic applications, by which disease-causing genes or viral miRNAs could be neutralized, or functional miRNAs be restored. Will bedside miRNA expression profiling eventually assist physicians in providing patients with accurate diagnosis, personalized therapy, and treatment outcome?fr
dc.publisherHumana Pressfr
dc.subjectSmall-interfering RNAsfr
dc.subjectRNA interferencefr
dc.subjectGene expressionfr
dc.subjectindividualized therapyfr
dc.titleRegulatory RNAs : future perspectives in diagnosis, prognosis, and individualized therapyfr
dc.typeCOAR1_1::Texte::Livre::Chapitre d'ouvragefr
dcterms.bibliographicCitationTarget Discovery and Validation Reviews and Protocols; Publié dans : Methods in Molecular Biology, vol
dc.subject.rvmPetits ARN interférentsfr
dc.subject.rvmExpression géniquefr
dc.subject.rvmMédecine personnaliséefr
dc.subject.rvmRibonucléase IIIfr
dc.subject.rvmInterférence ARNfr
rioxxterms.versionVersion of Recordfr
rioxxterms.project.funder_nameNatural Sciences and Engineering Research Council of Canadafr
rioxxterms.project.funder_nameHealth Canadafr
Collection:Chapitres de livre

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