Impact d'une prise en charge multidisciplinaire sur la fonctionnalité des particules HDL d'adolescents présentant un surplus pondéral

Authors: Gagnon, Katherine
Advisor: Blackburn, Patricia
Abstract: The prevalence of childhood obesity has significantly increased over the past decades. This increased have adverse effects on cardiovascular health, leading to early development of atherosclerosis. Obesity is associated with a reduced HDL cholesterol level and with a decreased efflux capacity of HDL particles. Recently, it has been shown that efflux capacity of HDL particles is inversely associated with the risk of coronary heart disease. However, only few studies have addressed this issue in obese adolescents. The main objective of this study was to assess the impact of a multidisciplinary intervention program on HDL cholesterol efflux capacity (CEC) in obese adolescents. Twenty-nine adolescents (16 boys and 13 girls) aged 11 to 16 years were involved in this study. The goal of the intervention was to improve eating habits and increase the level of physical activity. Each youth was followed by a multidisciplinary team and trained three sessions per week for 16 weeks. Results suggest that a multidisciplinary intervention program can help to improve risk profile and HDL CEC in obese adolescents. In addition, results indicate that changes in HDL CEC are related to changes in HDL cholesterol concentrations
Document Type: Mémoire de maîtrise
Issue Date: 2018
Open Access Date: 24 November 2018
Grantor: Université Laval
Collection:Thèses et mémoires

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