Modulation du chémoréflexe et de la stabilité respiratoire par les récepteurs nucléaires et membranaires de la progestérone
|Abstract:||Progesterone stimulates the ventilatory chemorefelx and reduces the occurrence of apnea, but the mechanisms are not well understood. The nuclear (nPR) and membrane progesterone receptors (mPRs) sutypes α and β are expressed in the respiratory centers of the brainstem. First, we postulated that the nPR deletion in female mice (PRKO) affects ventilatory chemoreflex and increases the frequency of apnea during the quiet sleep. Our results showed that the nPR stimulate the ventilatory response to hypercapnia and reduce the frequency of post-sigh apneas during the quiet sleep. Next, we postulated that the mPRα and mPRβ modulate chemoreflex and ventilatory stability in adult mice. The reduction of the expression of the mPRβ or the mPRα, expressed at the level of the ventilatory control centers at the level of the medulla oblongata, has demonstrated that these receptors contribute to the regulation of the ventilatory chemoreflex. In addition, mPRβ contributes to respiratory stability in male and female adult mice. Finally, we have postulated that reduced expression of the nPR, mPRα, or mPRβ in the central nervous system affects chemoreflex and ventilatory stability in 10-day-old rats. Our results indicated that the nPR and mPRβ contribute to the stability of the ventilatory pattern in neonates. We conclude that progesterone signals via nPR receptors, mPRα and mPRβ to regulate ventilatory chemorefelx in adults. In addition, nPR and mPR contribute to ventilatory stability in both adult mice and neonatal rats. These two receptors could be new therapeutic targets for the treatment of sleep apnea in adults and apnea of the newborn.|
|Document Type:||Thèse de doctorat|
|Open Access Date:||31 July 2018|
|Collection:||Thèses et mémoires|
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