L'impact du diabète gestationnel sur le profil de risque cardiométabolique des enfants exposés pendant leur période fœtale

Authors: Kearney, Michèle
Advisor: Robitaille, JulieMarc, Isabelle
Abstract: Gestational diabetes increases the risk of pregnancy and delivery adverse outcomes. Moreover, individuals exposed in utero may be at higher risk of developing health problems such as type 2 diabetes. Many studies aim to investigate the association between gestational diabetes exposure and increased adiposity during childhood, adolescence or adulthood. However, a majority of these studies used the body mass index as an adiposity measure. Other methods that estimate adipose tissue quantity and distribution with more accuracy could provide measures that are better associated with cardiometabolic risk and therefore, could help to better understand the impact of gestational diabetes exposure on health. In this context, this project aimed to study the association between prenatal exposure to gestational diabetes and cardiometabolic risk profile in children. More specifically, the aim of the study was to compare body composition and body fat distribution of children aged between three to twelve years old who had been exposed and non-exposed to gestational diabetes and to investigate if these adiposity measures were associated with glycemic profile. Results reveal an increased fat mass proportion and a more centralized body fat distribution in children born from a mother who experienced a diabetic pregnancy. Moreover, alterations observed in the body composition of children were associated with a detrimental glycemic profile. There is a need for more studies to understand when and how these cardiometabolic alterations are developing and to investigate if it is possible to prevent their emergence and later evolution into obesity or type 2 diabetes in the longer term.
Document Type: Mémoire de maîtrise
Issue Date: 2018
Open Access Date: 9 July 2018
Permalink: http://hdl.handle.net/20.500.11794/30328
Grantor: Université Laval
Collection:Thèses et mémoires

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