Intense dopamine innervation of the subventricular zone in Huntington’s disease

Authors: Bédard, CatherineWallman, Marie-JoséePourcher, EmmanuelleParent, AndréParent, Martin
Abstract: Dopamine exerts a robust promoting effect on adult neurogenesis. Here, we report the presence of an intense dopamine (tyrosine hydroxylase immunoreactive) zone along the ventricular border of the caudate nucleus in patients with Huntington’s disease, but not in age-matched controls. This thin (150–400 lm) paraventricular zone was composed of numerous small and densely packed dopamine axon varicosities and overlapped the deep layers of the subventricular zone. Immunoreactivity in the paraventricular zone was 50% higher than in adjacent striatal areas. This intense dopamine zone concurs with the striking increase of neurogenesis noted in the subventricular zone of Huntington’s disease patients and indicates that dopamine might play a crucial role in intrinsic mechanisms designed to compensate for the massive striatal neuronal losses that occur in Huntington’s disease
Document Type: Article de recherche
Issue Date: 31 August 2010
Open Access Date: Restricted access
Document version: VoR
This document was published in: NeuroReport, , Vol. 21 (17), 1074-1079 (2010)
Rapid Science Publishers
Alternative version: 10.1097/WNR.0b013e32834052a6
Collection:Autres articles publiés

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