Évaluation de la présence d'une protéinopathie dans le tremblement essentiel
|Abstract:||Various studies have led to the hypothesis that essential tremor (ET) is a syndrome resulting from a neurodegenerative process in the cerebellum. The collaboration with the neurologists, Dr Ali and Alex Rajput has allowed to a bank of post-mortem cerebellar cortices: 14 ET patients, 15 Parkinson disease (PD) patients and 20 control subjects. Most neurodegenerative diseases involve a proteinopathy, characterized by the accumulation of misfolded-proteins. I investigated common types of proteic abnormalities such as: synucleinopathies, « TAR DNA binding protein 43 » (TDP-43) and taupathies observed in classic neurodegenerative diseases, using Western immunoblotting. However, results do not indicate a distinctively the presence of a proteinopathy in ET cerebellum, except for a non-significant increase of tau epitopes AT100, a neuropathological marker of Alzheimer's disease (AD).|
|Document Type:||Mémoire de maîtrise|
|Open Access Date:||24 April 2018|
|Collection:||Thèses et mémoires|
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