Évaluation de la relation entre les apports en antioxydants et le niveau d'expression de marqueurs inflammatoires dans le tissu mammaire normal de femmes atteintes du cancer du sein

Authors: Larouche, Danielle
Advisor: Diorio, Caroline
Abstract: Diet plays an important role in the development of breast cancer, but the influence of dietary factors on the mammary tissue is poorly understood. One possible underlying mechanism is the generation of oxidative stress favoring inflammation and tumorigenic processes. Consequently, antioxidant consumption that fosters tissue inflammation reduction could prevent breast cancer risk. However, few studies have explored relationships between antioxidant intakes and inflammation marker expression in breast tissue. This project aimed to evaluate potential link between the intake of antioxidants that have been associated with breast cancer risk and the protein expression level of 11 inflammatory markers in normal breast tissue of 160 women diagnosed with breast cancer. Antioxidant intakes were collected using a self-administered semi-quantitative food frequency questionnaire designed to measure dietary patterns and supplement intake over the past year. Inflammation marker expression was assessed by immunohistochemistry. Correlations between antioxidant intakes and inflammatory marker expression were explored using the Spearman’s partial correlation coefficients (r) for all women, and then for premenopausal and postmenopausal women separately. After Bonferroni correction, negative correlations were observed between dietary beta-tocopherol and IL-10 expression in all women combined (r=-0.26) and among postmenopausal women (r=-0.39). For all women, negative correlation was found between total zinc intakes and IL-10 (r=-0.26). Among postmenopausal women, dietary selenium intake was negatively correlated with the expression of lactoferrin (r=-0.39). No associations were observed in premenopausal women. Our findings suggest that consumption of specific antioxidants, including beta-tocopherol, zinc and selenium, may act on the breast tissue through mechanisms affecting the expression of certain inflammation markers and that this would be influenced by the menopausal status.
Document Type: Mémoire de maîtrise
Issue Date: 2017
Open Access Date: 24 April 2018
Permalink: http://hdl.handle.net/20.500.11794/27701
Grantor: Université Laval
Collection:Thèses et mémoires

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