Dynamique d'infection des sous-populations lymphocytaires T CD4 chez le macaque Rhésus infecté par le Virus de l'Immunodéficience Simienne

Authors: Rabezanahary Aina, Henintsoa
Advisor: Estaquier, Jérôme
Abstract: During HIV infection, viral reservoirs are established early, and represent a major problem regarding their eradication. Understanding the basis of viral dissemination, particularly in deep tissues such as the spleen, which is difficult to analyze in Human, particularly during the early phase of infection, is a challenge for public health. Our hypothesis was to determine the contribution of a subset of CD4 T cells namely Tfh (T follicular helper cells) that play a major role in the establishment of humoral response and which is preponderant in the spleen. My results showed in rhesus macaques infected with simian immunodeficiency virus (SIV) that during the acute phase of infection, splenic Tfh cells are a target of the virus. This early infection of these cells could therefore contribute to the spread of infection and account for the lack of effective antibody response against the virus.
Document Type: Mémoire de maîtrise
Issue Date: 2015
Open Access Date: 24 April 2018
Permalink: http://hdl.handle.net/20.500.11794/27654
Grantor: Université Laval
Collection:Thèses et mémoires

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