Études dermopharmacologiques d'une nouvelle molécule destinée au traitement du psoriasis grâce à l'utilisation d'un modèle de substitut cutané pathologique optimisé

Authors: Gendreau, Isabelle
Advisor: Pouliot, RoxaneC. Gaudreault, René
Abstract: Psoriasis is a serious cutaneous disease for which there is currently no cure. In vitro psoriatic skin models could become new tools to assess the potency of new drugs during the development of new therapies. First, this study aimed to optimize the production of psoriatic skin substitutes by the self-assembly method, and then use them to assess the effectiveness of a new potentially antipsoriatic molecule, tBEU. Initially, healthy and psoriatic substitutes have been produced by the self-assembly method partially modified, using 6-well and 12-well plates. These experiments demonstrated that the 6-well plates were more effective for the production of reproducible substitutes and representative of psoriatic skin in vivo than the 12-well plates. Then, these substitutes were treated with tBEU, showing that this molecule decreases significantly keratinocytes proliferation and improves their differentiation. Thus, tBEU may eventually be used as an effective topical treatment for psoriasis.
Document Type: Mémoire de maîtrise
Issue Date: 2015
Open Access Date: 24 April 2018
Permalink: http://hdl.handle.net/20.500.11794/27545
Grantor: Université Laval
Collection:Thèses et mémoires

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