Expression de la protéase tissulaire HtrA1 et le pronostic des femmes atteintes de cancer épithélial de l'ovaire

Authors: Gagné, Andréanne
Advisor: Bairati, IsabelleTêtu, Bernard
Abstract: Background: The protease High Temperature Requirement Factor A1 (HtrA1) might be associated with prognosis in ovarian cancer (OC). Objective: To evaluate the effect of HtrA1 expression in tumoral tissues on prognosis of women with serous OC. Methods: A cohort study was conducted among 122 women with a serous OC treated at the CHU de Québec between 1993-2006. Tissue microarrays were immunostained for HtrA1. HtrA1 expression was assessed visually and by digital image analysis (% of positive nuclei). Cox regression multivariate models taking into account standard prognostic factors were used to estimate adjusted hazard ratios (HR) of progression and death. Results: Low percentage of HtrA1 marked nuclei was associated with lower risks of progression (visual HR=0.66, p=0.04, digital HR=0.63, p=0.03) and death (visual HR=0.69, p=0.09, digital HR=0.56, p=0.01). Conclusion: Nuclear downregulation of HtrA1 was associated with a better prognosis in women with serous OC.
Document Type: Mémoire de maîtrise
Issue Date: 2015
Open Access Date: 24 April 2018
Grantor: Université Laval
Collection:Thèses et mémoires

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