Contrôle adaptatif d'un bioréacteur cardiaque par algorithme génétique

Authors: Gosselin, Jérôme
Advisor: Ruel, JeanBégin-Drolet, André
Abstract: A proper functioning of the human heart is essential for maintaining a good quality of life. However, when the heart fails, some surgical procedures are necessary to prolong life expectancy. As part of a multidisciplinary project linking mechanical engineering to biomedical science, our team is working on the manufacture of heart valves entirely designed by tissue engineering. To achieve this, obtaining optimum mechanical properties is an important aspect for the biological tissues. To obtain these mechanical properties, an important tool was designed in a previous study : the cardiac bioreactor. Cardiac bioreactors allow the reproduction of the physiological environment of the heart, including flow and pressure conditions. It is crucial to properly control these conditions, as they play an important role in valvular substitutes conditioning. However, it is complex to simultaneously control both conditions effectively. This is why our team has focused on developing a new control strategy so that the bioreactor can reproduce as faithfully as possible the physiological environment. Several control techniques have been experimented so far. However, accuracy was generally limited. So, a new approach has been considered and is presented here. This new approach is based on a well-known optimisation technique that is still quite unusual for control: genetic algorithms. This promising approach has allowed us to produce unprecedented results for one of the two conditions, the physiological flow.
Document Type: Mémoire de maîtrise
Issue Date: 2016
Open Access Date: 24 April 2018
Permalink: http://hdl.handle.net/20.500.11794/27003
Grantor: Université Laval
Collection:Thèses et mémoires

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